https://www.markslab.org/home daily 1.0 2025-09-10 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1560524785551-XCUC8ITWLFRS0RVR3W96/Ollie_blk.jpg Home https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1561135471640-FQSKJXTPL3ZYEURBKEGG/SPURSbanner.jpg Home https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1561733096116-T8ZY8RQ3KX98FNK289YT/RyRbanner2.jpg Home https://www.markslab.org/annual-report-mentor daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1560528514100-O2OH42LL7V3WWE3UD5UL/anetta2b.jpg Annual Report https://images.squarespace-cdn.com/content/v1/5797de498419c2b3b97221ba/1473796294701-PJQ9Y6BA21LY5I3H77MP/solid-52c2c8-2500x1667.jpg Annual Report https://images.squarespace-cdn.com/content/v1/5797de498419c2b3b97221ba/1473700888618-FTWE0952TOEB5FN2LMRP/annual-report-p1423927103-6-2500x1667.jpg Annual Report - 98% Student Retention DESCRIPTION TEXT. PELLENTE MORBI TRISTIQUE SENECTUS ET NETUS ET ET MALESUADA FAMES https://images.squarespace-cdn.com/content/v1/5797de498419c2b3b97221ba/1473700599108-USBOQA8JYVRAQKFNRVQV/annual-report-p1423939271-6-2500x1667.jpg Annual Report - 52% Female Students DESCRIPTION TEXT. MORBI TRISTIQUE SENECTUS ET NETUS ET MALESUADA FAMES PELLENTESQUE https://images.squarespace-cdn.com/content/v1/5797de498419c2b3b97221ba/1473701416958-FKF17V7V8TVLS9KF3TKD/annual-report-p1423758687-6-2500x1667.jpg Annual Report - Quisque Malesuada Vulputate DESCRIPTION TEXT. AMET DICTUM MAGNA SIT AMET MALESUADA LIBERO MORBI ODIO URNA, RHONCUS VITAE. https://images.squarespace-cdn.com/content/v1/5797de498419c2b3b97221ba/1473701632939-F6JOGA1G80DDEH1NJNIU/image-asset.jpeg Annual Report https://images.squarespace-cdn.com/content/v1/5797de498419c2b3b97221ba/1473701254951-GFL38KHA3FYXDFFL3BY9/image-asset.jpeg Annual Report https://www.markslab.org/alumni daily 0.75 2021-07-16 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1561568906476-RQK2O0HO0O7H5N99UBWR/columbia-univ-campus.jpg Alumni https://www.markslab.org/postdoc daily 0.75 2021-08-05 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1560792022782-GW1D04A29581XR3864WE/research.jpg Post Doc Positions https://www.markslab.org/contact-us daily 0.75 2019-06-07 https://www.markslab.org/our-research daily 0.75 2021-02-04 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1612111931114-BBOMBGBMVSP9WE2800U7/RyR2021.jpg Our Research https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1612042274185-K4T05AFFZJL53G2QKJ7G/image10.png Our Research https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1612042462613-B0XFAW9C22B0LERTRWE7/image18.png Our Research We have recently solved the structure of the human recombinant cardiac ryanodine receptor calcium release channel (RyR2) using cryogenic electron microscopy (cryo-EM) at ~2.5 Å (by Marco Miotto et al, manuscript in preparation). Here are shown (upper panel) a top down view, and (lower panel) a side view of the channel in the closed state. The mushroom shaped channel is comprised of an enormous cytoplasmic domain seated on a transmembrane stalk. Solving the atomic resolution structure of the RyR channels has enabled us to identify binding sites for key regulators of channel function, locate disease causing mutations, define the molecular interactions between the channel and its multiple subunits and binding partners, and locate drug binding sites. https://www.markslab.org/contact-us1 daily 0.75 2022-01-19 https://www.markslab.org/graduate-positions daily 0.75 2021-08-05 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1560793168129-TRV5M2LGLJK2XHFRROQU/BERRIE.jpg Graduate Positions Columbia University | Russ Berrie Medical Science Pavilion, home of the Marks lab https://www.markslab.org/publications daily 0.75 2025-10-29 https://www.markslab.org/admin daily 0.75 2025-12-17 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/46b9256b-3950-4784-999a-a6daae25e8a0/Ivy+Lei.jpg Admin Staff Ivy Lei Administrative Coordinator TEL: 212-851-5342 FAX: 212-851-5346 il2405@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1573490825161-75L4CRPOELRGVFOG4EO1/Matt.JPG Admin Staff Matthew Wallace Director of Budget and Financial Analysis TEL: 212-851-5343 FAX: 212-851-5346 mw2548@cumc.columbia.edu https://www.markslab.org/members daily 0.75 2025-02-24 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/369666cd-079b-402b-a0be-e1204343f7c9/Dridi.jpg Lab Members Haikel Dridi, PhD Université de Montpellier Assistant Professor Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) dridi.haikel1@gmail.com https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1776f88b-ffb4-4576-8950-52876896f12d/IMG_9100.JPG Lab Members Yang Liu, PhD Chinese Academy of Science Postdoctoral Research Scientist Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5377 212-851-5346 (FAX) yl4452@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1824ba46-31db-4b37-97ba-f0f7d471ca2a/Kaniz.jpeg Lab Members Kaniz Hossain, PhD Hokkaido University, Japan Postdoctoral Research Scientist Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) kh3105@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/a08f93e9-433b-4d15-a8f9-859455a00cd3/Anetta.jpg Lab Members Anetta E. Wronska, PhD Medical University of Warsaw Assistant Professor Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5347 212-851-5346 (FAX) aew2116@columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1609971972193-N2QQCH11O5K58SMYXW43/Gunnar.png Lab Members Gunner Weninger, PhD Leibniz University of Hannover, Germany Postdoctoral Research Scientist Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5377 212-851-5346 (FAX) gw2424@columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/8d26844c-1353-4f34-81b1-52aa304446ba/Carl.jpg Lab Members - Make it stand out Carl Tchagou Technician B Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) ctt2120@columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1572457680926-828OACW5ML74T02VAY1T/Qi.jpg Lab Members Qi Yuan, PhD Chinese Academy of Science Postdoctoral Research Scientist Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5347 212-851-5346 (FAX) qy2159@columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1572456949740-FMFVPXNZ9DVGCZ22E3MO/Marco.jpg Lab Members - Make it stand out Marco Miotto, PhD Universidad Nacional de Rosario Argentina Postdoctoral Research Scientist Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5377 212-851-5346 (FAX) mm5642@columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/72e9c4b9-4a4e-46a2-b787-3f447d78a47d/Chang.JPG Lab Members - Make it stand out Alexander Chang Johns Hopkins University Technician B 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1572456628096-MFLV6XI3E085B95NM8KR/Reiken.jpg Lab Members Steve Reiken, PhD Michigan State Assistant Professor Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) sr372@columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/04a021dd-b40d-427e-a2b7-818a24af215f/IMG_9094.jpg Lab Members - Make it stand out Julianna Montanez, B.S. Georgia State University Graduate Student Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/30fc08c9-eb26-4e7a-ba66-44d5fc72af40/Estefania.jpg Lab Members - Make it stand out Estefania Luna Figueroa University of Texas Rio Grande Valley Graduate Student Department of Physiology 1150 St. Nicholas Avenue New York, NY 10032 212-851-5348 212-851-5346 (FAX) el3257@cumc.columbia.edu https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/12ee98f3-fa90-4b8e-887a-80e3ea3cae63/Lab.jpg Lab Members https://www.markslab.org/andrew-marks daily 0.75 2025-03-03 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1611507443847-8XCGXT6OAATITNIQO9T3/office2.jpg Andrew Marks ANDREW R. MARKS, COLUMBIA UNIVERSITY https://www.markslab.org/footer daily 0.75 2019-07-03 https://www.markslab.org/quote daily 0.75 2019-07-03 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1560524785551-XCUC8ITWLFRS0RVR3W96/Ollie_blk.jpg Quote https://www.markslab.org/feature daily 0.75 2019-07-03 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1560524785551-XCUC8ITWLFRS0RVR3W96/Ollie_blk.jpg Feature https://www.markslab.org/timeline-of-ryr daily 0.75 2020-01-16 https://www.markslab.org/news-events daily 0.75 2020-02-05 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1580925872122-YWTGXJFKPR9NTXBQS56V/Francis.jpg News & Events Frances Forrester graduates on May 15, 2018 - receives her PhD with Dr. Marks and Yinghui Mao, PhD - Assistant Dean for Graduate Affairs https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1580927239629-K2LTMQOOVEI501Z2U3SJ/250yrs.jpg News & Events Columbia celebrates its founding 250 years ago in The Roy and Diana Vagelos Education Center https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1580926418248-9BCUJ293IXHFLDCLVQQF/congrats.jpg News & Events Dr. Andrew Marks congratulates his lab manager Steve Reiken for 20 years of successful and dedicated service. https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1580927299180-H7C8LCHNHK9GGPM97972/group2012.jpg News & Events Marks Lab Retreat Bear Mountain New York, New York https://www.markslab.org/covid19 daily 0.75 2020-10-26 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1584217046679-R90GZX5IIHRV9GR2O3EC/Covid19banner.png COVID-19 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1584216844622-ALAVTCKT579UMAHHLY0J/Timeslogo.png COVID-19 https://www.markslab.org/new-page daily 0.75 2020-10-26 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/1584734349354-XS9V0PGXC968F4Y3N7L7/SKorea2.jpg South Korea A man disinfects a street in Seoul, South Korea, on 18 March 2020: ‘South Korea has been effective in controlling its mortality rate through widespread rigorous measures.’ Photograph: Chung Sung-Jun/Getty Images https://www.markslab.org/editorial daily 0.75 2025-02-13 https://www.markslab.org/kandel daily 0.75 2023-02-13 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/63072ae4-404f-4150-bc99-04262a77c066/EricKandel.jpg Kandel Eric Kandel, the Nobel Prize-winning scientist, University Professor, Sagol Professor of Brain Science, Codirector of Columbia’s Zuckerman Institute, Founding Director of Columbia’s Kavli Institute for Brain Science, and Senior Investigator at the Howard Hughes Medical Institute. https://www.markslab.org/awards daily 0.75 2026-02-18 https://images.squarespace-cdn.com/content/v1/5cfa980aa2842700016e076a/a0a00a3b-5762-4614-89a9-55bf48e08ea4/ARM1B.jpg Awards Andrew R. Marks, M.D. Chairman and Professor of Physiology & Cellular Biophysics